RNA-Seq Scientist

190 - Informatics · Berkeley, California
Department 190 - Informatics
Employment Type Full-Time
Minimum Experience Mid-level

Caribou Biosciences, Inc. is a leading clinical-stage CRISPR genome editing biotechnology company located in Berkeley, CA. Caribou's tools and technologies provide transformative capabilities to therapeutic development and the company is advancing an internal pipeline of genome-edited cell therapies for various oncology indications. Caribou was founded in 2011 by CRISPR pioneers including Nobel Prize winner Jennifer Doudna, PhD, Martin Jinek, PhD, and Rachel Haurwitz, PhD, our President and CEO. The company has developed a novel CRISPR genome editing technology platform and has a leading intellectual property position.


At Caribou, every employee is valued for their unique perspective, background, and diversity. Every person on the Caribou team contributes to problem solving and innovation. The Company’s vision is to advance agile genome editing innovations for the benefit of our communities. 


We are seeking a subject matter expert in single cell RNA-Sequencing (scRNA-Seq) and related technologies to establish and run a core transcriptomics lab.  In this newly created role, you will make a significant impact on the development of cell therapies by establishing the platform for transcriptomic profiling across multiple projects and functional teams at Caribou.  You will bring a collaborative spirit in addition to hands-on experience both performing scRNA-Seq experiments and analyzing the results in the context of other functional and genomic attributes. As part of Caribou's computational biology team, you will ensure that transcriptomic data enhances the characterization of our engineered cell products at all stages of the development process. In addition, you will own the laboratory systems and procedures required to produce consistently high-quality results. This includes preparing samples, performing actual scRNA-Seq experiments, coordinating with our NGS team, developing SOPs, training and nurturing other scientists and RAs, and maintaining relevant instrumentation.   


Primary Responsibilities:


  • Take lead in deploying in-house single-cell RNA sequencing capabilities at Caribou.  
  • Serve as the primary point of contact for scRNA-Seq and related technologies (e.g. single cell immune profiling, chromatin accessibility, etc.)
  • Work closely with Caribou project and functional teams to tailor the assay and analysis for specific use cases
  • Ensure consistency and reproducibility of transcriptomic profiles over time to support longitudinal characterization of engineered cell products
  • Work closely with Caribou NGS sequencing team
  • Develop key documentation including SOPs and training plans
  • Train other scientists and RAs to run single cell experiments   


Minimum Qualifications

  • PhD in Molecular Biology, Cellular Biology, Genomics, Informatics, or related fields
  • Extensive experience with single cell RNA sequencing and traditional molecular and cell biology skills such as: cell culture, cloning, PCR, library construction, flow cytometry
  • Informatics domain knowledge
  • Deep understanding of the scRNA-Seq assay, relevant analytical approaches, and key applications


Nice-to-have (but not required)

  • Demonstrated proficiency coding in Python, NumPy/SciPy, R, Tableau, and/or JavaScript to support efficient analytical pipelines, statistical analyses, and visualizations
  • Experience with NGS sequencing, Nextera library preparation, and related technologies
  • Experience with source code control and software development best practices
  • Post-doctoral research experience in immuno-oncology or immunology


Caribou Biosciences, Inc. is a dynamic start-up biotechnology company, and the successful candidate should have a passion for science and a desire to work in a collaborative environment. Caribou promotes a culture in which employees are respected and valued for hard work, innovation, personal initiative, and teamwork.  

Caribou compensation and benefits:

  • Comprehensive compensation package including stock options
  • Generous paid vacation time in addition to Company-observed holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan including matching employer contributions
  • Tuition reimbursement program


Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.  Legal authorization to work in the U.S. is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. 

Caribou is on Twitter. Follow the Company @CaribouBio.

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  • Location
    Berkeley, California
  • Department
    190 - Informatics
  • Employment Type
  • Minimum Experience