Scientist, Genome Editing Technology Development

130 - Technology Development · Berkeley, California
Department 130 - Technology Development
Employment Type Full-Time
Minimum Experience Mid-level

Caribou Biosciences is a clinical-stage biopharmaceutical company founded in 2011 by pioneers in CRISPR genome editing and headquartered in Berkeley, California. The company’s mission is to develop innovative, transformative therapies for patients with devastating diseases through novel genome editing. Caribou leverages its proprietary technologies to develop a wholly owned pipeline of genome-edited, off-the-shelf immune cell therapies, including CAR-Ts and CAR-NKs, for the treatment of multiple different types of cancer. Caribou believes that advanced genome editing is necessary to develop sophisticated cell therapies to treat a variety of malignancies.

Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, their contributions are recognized, and their needs are met.


We are seeking a protein biochemist Scientist to join our Technology Development group in Berkeley.  This individual will interact closely with Caribou Scientists to build and engineer new CRISPR-based tools for therapeutic genome editing.  The successful candidate will have extensive, hands-on experience with protein engineering and optimization, a passion for working on highly novel, early-stage prototypes, and a clear record of being able to move projects forward.  This is an opportunity for a creative scientist to work in a highly matrixed team environment to drive tool development and shape Caribou’s next-generation cell therapy programs.


Key Responsibilities:

  • Design, express, and functionally characterize CRISPR-based tools for mammalian genome editing
  • Propose and implement innovative approaches (e.g., structure-based protein engineering, rational mutagenesis, directed evolution) to optimize protein activity
  • Collaborate with Caribou scientists to perform and analyze mammalian genome editing experiments
  • Communicate results clearly and concisely, internally and externally
  • Keep accurate record of experiments and results
  • Mentor junior team members to help them troubleshooting their experiments


Candidate must possess:


  • PhD in structural biology, biochemistry, molecular biology, or a closely related field
  • Minimum 2 years of relevant experience
  • Extensive experience with protein engineering for tool development, molecular biology, DNA assembly and construct design
  • Strong background in protein purification, biochemical assay development, enzyme kinetics
  • Experience with genome editing tools and technologies
  • Excellent interpersonal, verbal, and written communication skills
  • Strong desire to do work on early-stage technology development, to implement creative approaches to expand Caribou’s genome editing toolkit and intellectual property 


Additional positives:

  • Experience with CRISPR-based tools
  • Experience with drafting and filing patents
  • Experience with Next-Generation Sequencing (NGS) technologies
  • Familiarity molecular visualization software (Pymol, QTMG, etc.)
  • Experience with cell culture and transfection


Caribou compensation and benefits include:

  • Comprehensive compensation package including stock options and employee stock purchase program
  • Generous paid vacation time in addition to Company-observed holidays and floating holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan including matching employer contributions
  • Tuition reimbursement program


Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. 


Caribou is on Twitter. Follow the Company @CaribouBio.

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  • Location
    Berkeley, California
  • Department
    130 - Technology Development
  • Employment Type
  • Minimum Experience