Scientist, Genome Editing Technology Development

130 - Technology Development · Berkeley, California
Department 130 - Technology Development
Employment Type Full-Time
Minimum Experience Mid-level

Caribou Biosciences, Inc. is a leading clinical-stage CRISPR genome editing biotechnology company located in Berkeley, CA. Caribou's tools and technologies provide transformative capabilities to therapeutic development and the company is advancing an internal pipeline of genome-edited cell therapies for various oncology indications. Caribou was founded in 2011 by CRISPR pioneers including Nobel Prize winner Jennifer Doudna, PhD, Martin Jinek, PhD, and Rachel Haurwitz, PhD, our President and CEO. The company has developed a novel CRISPR genome editing technology platform and has a leading intellectual property position.


At Caribou, every employee is valued for their unique perspective, background, and diversity. Every person on the Caribou team contributes to problem solving and innovation. The Company’s vision is to advance agile genome editing innovations for the benefit of our communities.


We are seeking a protein biochemist Scientist to join our Technology Development group in Berkeley.  This individual will interact closely with Caribou Scientists to build and engineer new CRISPR-based tools for therapeutic genome editing.  The successful candidate will have extensive, hands-on experience with protein engineering and optimization, a passion for working on highly novel, early-stage prototypes, and a clear record of being able to move projects forward.  This is an opportunity for a creative scientist to work in a highly matrixed team environment to drive tool development and shape Caribou’s next-generation cell therapy programs.


Key Responsibilities:

  • Design, express, and functionally characterize CRISPR-based tools for mammalian genome editing
  • Propose and implement innovative approaches (e.g., structure-based protein engineering, rational mutagenesis, directed evolution) to optimize protein activity
  • Collaborate with Caribou scientists to perform and analyze mammalian genome editing experiments
  • Communicate results clearly and concisely, internally and externally
  • Keep accurate record of experiments and results
  • Mentor junior team members to help them troubleshooting their experiments


Candidate must possess:


  • PhD in structural biology, biochemistry, molecular biology, or a closely related field
  • Minimum 2 years of relevant experience
  • Extensive experience with protein engineering for tool development, molecular biology, DNA assembly and construct design
  • Strong background in protein purification, biochemical assay development, enzyme kinetics
  • Experience with genome editing tools and technologies
  • Excellent interpersonal, verbal, and written communication skills
  • Strong desire to do work on early-stage technology development, to implement creative approaches to expand Caribou’s genome editing toolkit and intellectual property 


Additional positives:

  • Experience with CRISPR-based tools
  • Experience with drafting and filing patents
  • Experience with Next-Generation Sequencing (NGS) technologies
  • Familiarity molecular visualization software (Pymol, QTMG, etc.)
  • Experience with cell culture and transfection


Caribou Biosciences, Inc. is a dynamic start-up biotechnology company, and the successful candidate should have a passion for science and a desire to work in a collaborative environment. Caribou promotes a culture in which employees are respected and valued for hard work, innovation, personal initiative, and teamwork.


Caribou compensation and benefits:

  • Comprehensive compensation package including stock options
  • Generous paid vacation time in addition to Company-observed holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan including matching employer contributions
  • Tuition reimbursement program


For more information, please visit Caribou is on Twitter. Follow the Company @CaribouBio.


Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.

Direct applicants only. No agencies please.

Thank You

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  • Location
    Berkeley, California
  • Department
    130 - Technology Development
  • Employment Type
  • Minimum Experience