Senior Research Associate, CAR-T Cell Therapies

120 - T Cell Therapeutics · Berkeley, California
Department 120 - T Cell Therapeutics
Employment Type Full-Time
Minimum Experience Mid-level

Caribou Biosciences, Inc. is a leading clinical-stage CRISPR genome editing biotechnology company located in Berkeley, CA. Caribou's tools and technologies provide transformative capabilities to therapeutic development and the company is advancing an internal pipeline of genome-edited cell therapies for various oncology indications. Caribou was founded in 2011 by CRISPR pioneers including Nobel Prize winner Jennifer Doudna, PhD, Martin Jinek, PhD, and Rachel Haurwitz, PhD, our President and CEO. The company has developed a best-in-class CRISPR genome editing technology platform and has a leading intellectual property position.

 

At Caribou, every employee is valued for their unique perspective, background, and diversity. Every person on the Caribou team contributes to problem solving and innovation. The Company’s vision is to advance agile genome editing innovations for the benefit of our communities.

 

As a result of exciting developments both with Caribou’s internal pipeline programs and with the addition of a significant new external partnership, we have multiple early-stage projects at Caribou focused on the preclinical discovery and development of CAR-T cell therapy candidates. We are looking for experienced Senior Research Associates to help us propel this work forward. Using collaborative teamwork, as well as your experience and winning spirit, you will work closely and cross-functionally with other researchers on cutting-edge technologies to deliver on impactful research projects that we believe will ultimately positively impact the lives of patients. You will work with cutting edge science and have the opportunity to contribute broadly across multiple technical areas in the process of cell therapy candidate development. 

 

Responsibilities include:

  • Culturing primary human immune cells, including isolation, activation and expansion from PBMCs
  • Genome engineering using nucleofection and viral transduction procedures and advanced CRISPR gene editing technologies
  • Screening of scFvs for preclinical CAR-T programs using immune cell biology-based assays, including in vitro cytotoxicity and cytokine production assays
  • Multi-color flow cytometry and data analysis using FlowJo and Forecyt
  • Additional technical work may also include maintenance and expansion of tumor cell lines, proliferation assays, and lentiviral production and transduction to generate new target cell lines
  • Advanced level work may include strategizing CAR construct designs and development of novel in vitro functional assays to characterize CAR-T function
  • Coordinating experiments with other Scientists and RAs across functional groups
  • Documenting, analyzing and presenting data at internal meetings
  • Serve as a technical expert and mentor for other Research Associates as we expand and develop our project teams with the potential to manage junior associates
  • Provide leadership and technical guidance to further the development of best-in-class allogeneic CAR-T cell therapy products

 

Qualifications:

  • Bachelor’s degree, Master’s degree or equivalent experience in Cell Biology, Immunology, Biochemistry, Molecular Biology or a related discipline
  • Minimum of 5 years of experience working in immunology or oncology research operations performing cell-based assays
  • Extensive experience in mammalian cell culture techniques, including primary cell culture
  • Broad experience with flow cytometry
  • Application of genome editing technologies
  • Demonstrated ability to solve challenging problems in cell-based assay development
  • Strong communication skills, self-motivation and proven ability to work in a team environment and independently
  • Experience with technical report writing
  • Ability to synthesize ideas and troubleshoot solutions using relevant primary literature
  • Willingness and ability to share occasional weekend cell culture duties

 

Nice-to-have (but not required):

  • High-throughput assay development
  • Experience evaluating therapeutic candidates in animal models
  • Experience with lab automation
  • Experience mentoring/training Research Associates at various levels
  • Prior experience working with cellular therapies or CRISPR technologies 

 

Note: We also have Research Associate opportunities for non-Senior candidates on our expanding CAR-T Cell Therapies team. Learn more and apply here:  https://cariboubio.bamboohr.com/jobs/view.php?id=115


Caribou Biosciences, Inc. is a dynamic start-up biotechnology company, and the successful candidate should have a passion for science and a desire to work in a collaborative environment. Caribou promotes a culture in which employees are respected and valued for hard work, innovation, personal initiative, and teamwork.  


Caribou compensation and benefits:

  • Comprehensive compensation package including stock options
  • Generous paid vacation time in addition to Company-observed holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan including matching employer contributions
  • Tuition reimbursement program


Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.  Legal authorization to work in the U.S. is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. 


Caribou is on Twitter. Follow the Company @CaribouBio.

Thank You

Your application was submitted successfully.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

  • Location
    Berkeley, California
  • Department
    120 - T Cell Therapeutics
  • Employment Type
    Full-Time
  • Minimum Experience
    Mid-level