Scientist/Senior Scientist, CAR-T Cell Therapies

120 - T Cell Therapeutics · Berkeley, California
Department 120 - T Cell Therapeutics
Employment Type Full-Time
Minimum Experience Mid-level

Caribou Biosciences, Inc. is a leading clinical-stage CRISPR genome editing biotechnology company located in Berkeley, CA. Caribou's tools and technologies provide transformative capabilities to therapeutic development and the company is advancing an internal pipeline of genome-edited cell therapies for various oncology indications. Caribou was founded in 2011 by CRISPR pioneers including Nobel Prize winner Jennifer Doudna, PhD, Martin Jinek, PhD, and Rachel Haurwitz, PhD, our President and CEO. The company has developed a novel CRISPR genome editing technology platform and has a leading intellectual property position.


At Caribou, every employee is valued for their unique perspective, background, and diversity. Every person on the Caribou team contributes to problem solving and innovation. The Company’s vision is to advance agile genome editing innovations for the benefit of our communities.


As a result of exciting developments both with Caribou’s internal pipeline programs and with the addition of a significant new external partnership, we have multiple early-stage projects at Caribou focused on the preclinical discovery and development of CAR-T cell therapy candidates. We are seeking an immune cell engineering Scientist/Senior Scientist to join our T-Cell Therapeutics group. Working in a collaborative environment, you will contribute your thorough understanding of immunology, as it relates to tumor biology, to propel this work forward into product development. This is an opportunity for a talented scientist to drive discovery and to shape Caribou’s next-generation cell therapy programs.


Responsibilities include:


  • Working with a highly matrixed team to develop and advance preclinical allogeneic CAR-T cell programs targeting liquid and/or solid tumors
  • Designing, coordinating, executing, and analyzing in vitro and in vivo experiments
  • Developing in vitro functional assays for the characterization of allogeneic CAR-T cell therapy candidates
  • Creative thinking to propose and implement innovative cell engineering approaches to expand Caribou’s preclinical pipeline and intellectual property
  • Communicating results clearly and concisely internally and externally
  • Keeping accurate record of experiments and results


Candidate must possess:


  • PhD in immunology, molecular biology, cell biology, or a closely related field
  • Minimum 2 years of relevant experience (postdoctoral or industry)
  • Hands-on proficiency in primary immune cell isolation and culture
  • Experience in planning and executing in vitro functional assays to characterize primary immune cells including, but not limited to, cytotoxicity assays, cytokine/chemokine measurements, and proliferation assessment
  • Experience in multi-parameter flow cytometry and data analysis
  • Excellent interpersonal, verbal, and written communication skills are essential in our collaborative research environment
  • Ability to develop and mentor a team of researchers
  • Comfort in a fast-paced environment and ability to adjust workload based upon changing priorities


Desired experience:


  • Understanding of genome editing techniques
  • Prior experience with cell therapies or other biologics
  • Work in pharmaceutical or biotechnology company focused on immuno-oncology
  • Understanding of regulatory guidelines for cell therapies


Caribou Biosciences, Inc. is a dynamic start-up biotechnology company, and the successful candidate should have a passion for science and a desire to work in a collaborative environment. Caribou promotes a culture in which employees are respected and valued for hard work, innovation, personal initiative, and teamwork. 


Caribou compensation and benefits:

  • Comprehensive compensation package including stock options
  • Generous paid vacation time in addition to Company-observed holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan including matching employer contributions
  • Tuition reimbursement program


Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.  Legal authorization to work in the U.S. is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.


For more information, please visit Caribou is on Twitter. Follow the Company @CaribouBio.



Direct applicants only. No agencies please.


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  • Location
    Berkeley, California
  • Department
    120 - T Cell Therapeutics
  • Employment Type
  • Minimum Experience