Executive Director/Vice President of Pharmacology

125 - In-vivo Pharmacology · Berkeley, California
Department 125 - In-vivo Pharmacology
Employment Type Full-Time
Minimum Experience Executive

Caribou Biosciences, Inc. is a leading clinical-stage CRISPR genome editing biotechnology company located in Berkeley, CA. Caribou's tools and technologies provide transformative capabilities to therapeutic development and the company is advancing an internal pipeline of genome-edited cell therapies for various oncology indications. Caribou was founded in 2011 by CRISPR pioneers including Nobel Prize winner Jennifer Doudna, PhD, Martin Jinek, PhD, and Rachel Haurwitz, PhD, our President and CEO. The company has developed a novel CRISPR genome editing technology platform and has a leading intellectual property position.


At Caribou, every employee is valued for their unique perspective, background, and diversity. Every person on the Caribou team contributes to problem solving and innovation. The Company’s vision is to advance agile genome editing innovations for the benefit of our communities.


The Company is seeking an Executive Director/Vice President of Pharmacology who will direct, plan, and guide the research of the in vivo modeling group as well as make critical go/no-go decisions for the Company. We are seeking an experienced pharmacologist to oversee the design, delivery, and interpretation of preclinical pharmacology data in support of our research pipeline. The self-motivated and motivational candidate will engage with interdisciplinary research teams to provide guidance on pharmacology models and strategy; prioritize and manage the pharmacology workflow; manage and grow a team of direct reports; actively participate in the IACUC; and be responsible for the preparation of technical reports and summaries for regulatory submission.


Duties and responsibilities:

  • Lead, mentor, and build a group of pharmacology scientists and research associates
  • Plan, design, conduct, and report on team research efforts
  • Train group members in surgical techniques for orthotopic solid tumor xenograft models
  • Develop patient-derived xenograft (PDX) models for both solid and liquid tumors
  • Direct team, monitor outcomes, implement modifications, write reports, and prepare/deliver presentations
  • Coordinate with research teams to select or develop appropriate models and identify outsourcing opportunities for specialized models
  • Design and troubleshoot complex experiments using extensive knowledge and expertise in specialized field of study
  • Review, analyze, and interpret experimental results
  • Supervise and oversee maintenance and acquisition of lab instruments
  • Determine clear “go/no-go” criteria based on balance of risk versus reward
  • Bring new ideas forward for implementation into model or technology development
  • Provide guidance to direct reports and collaborating staff on technical issues
  • Support patent development efforts from innovation disclosures to applications


Candidate must have the following qualifications:

  • PhD degree in pharmacology, immunology, cancer biology or a related field, and 15+ years of relevant industry experience with 5 or more years of management experience
  • Detailed understanding of mouse tumor models, and their implementation in oncology therapy development
  • Thorough understanding of laboratory animal science, and the role of the IACUC
  • Experience with multiple routes of therapeutic administration
  • Ability to prioritize, anticipate challenges, execute on goals, and manage ambiguity
  • Recognized as scientific and team leader having presented at national/international meetings and/or to external parties on a broad array of topics
  • Demonstrated knowledge of complex concepts gained through advanced education or experience
  • Contributed significantly to publications, patents, and presentations and has been first or last author on publications
  • Organized and effective communicator
  • Experience with cell therapies in pharmacology evaluation is a plus


Caribou Biosciences, Inc. is a dynamic biotechnology company, and the successful candidate should have a passion for science and a desire to work in a collaborative environment. Caribou promotes a culture in which employees are respected and valued for hard work, innovation, personal initiative, and teamwork.  


Caribou compensation and benefits:

  • Comprehensive compensation package including stock options
  • Generous paid vacation time in addition to Company-observed holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan including matching employer contributions
  • Tuition reimbursement program


Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.  Legal authorization to work in the U.S. is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. 


Caribou is on Twitter. Follow the Company @CaribouBio.


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  • Location
    Berkeley, California
  • Department
    125 - In-vivo Pharmacology
  • Employment Type
  • Minimum Experience