Vice President/Senior Vice President of Translational Sciences

125 - In-vivo Pharmacology · Berkeley, California
Department 125 - In-vivo Pharmacology
Employment Type Full-Time
Minimum Experience Executive

Caribou Biosciences is a clinical-stage biopharmaceutical company founded in 2011 by pioneers in CRISPR genome editing and headquartered in Berkeley, California. The company’s mission is to develop innovative, transformative therapies for patients with devastating diseases through novel genome editing. Caribou leverages its proprietary technologies to develop a wholly owned pipeline of genome-edited, off-the-shelf immune cell therapies, including CAR-Ts and CAR-NKs, for the treatment of multiple different types of cancer. Caribou believes that advanced genome editing is necessary to develop sophisticated cell therapies to treat a variety of malignancies.


Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, their contributions are recognized, and their needs are met.

 

We are seeking a Vice President/Senior Vice President of Translational Sciences to join the R&D organization to develop our capabilities in translating research activities to clinical applications. The candidate will oversee development and validation of biomarker assays for their implementation and evaluation in clinical studies. Additionally, the candidate will interact with the therapeutic discovery teams, the technical operations group, and the clinical team to develop and implement strategies for therapeutic development, strategies for potency assay development, and applications of biomarker assays across clinical programs. The candidate will have strong experience and familiarity with oncology therapeutic development, particularly cell therapies, as well as clinical trials for different malignancies. Experience in the development of companion diagnostics is a plus.

 

Primary Responsibilities and Duties:

  • Lead biomarker activities dedicated to delivering translational and biomarker strategies for the portfolio of allogeneic cell therapeutics
  • Partner within a highly matrixed organization, acting as the key interface between groups including discovery research, technical operations, regulatory affairs, translational medicine, clinical development and project leadership, and also with external partners, to deliver on high-quality biomarker plans for all product candidate programs
  • Provide guidance, oversight, scientific input, and biomarker expertise for execution and review of all aspects of early development plans, academic collaborations including resultant publications and posters, and for relevant internal documents (regulatory submissions, sample collection tables, sample collection instructions and logistics, investigator brochures, and clinical protocols)
  • Ensure the output of the biomarker plans meets established program standards (within budget, on schedule, compliance, etc.), while looking for opportunities to streamline progress without compromising quality, making sure that Translational Sciences is focused on key assets, and that plans are integrated within the broader Translational strategy
  • Ensure the progress of translational plans into their implementation and execution through internal assay execution and/or development with external contract research organizations (CROs) and specialty testing labs
  • Support due diligence and asset integration activities as needed. Proactively provide insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging therapy profiles
  • Communicate key biomarker program information, risks, risk mitigation and milestones, and manage information flow across key stakeholders including therapeutic area leadership, functional leads, and team members
  • Independently engage with development teams and technical/scientific experts to define, revise and progress biomarker plans
  • Collaborate and strategize across the entire organization to improve efficiency and accelerate the product pipeline forward
  • Participate in strategic overview of presentations, publications, and internal/external communications along with accountable program leadership
  • Balance multiple priorities in a fast-paced, team-based environment and work independently when needed, building structure from ambiguity, and helping teams to develop priorities
  • Ensure compliance with cGMP, GLP, and regulatory guidelines

 

Candidate must possess:

  • Minimum of 15 years of post-PhD industry experience in translational science or pharmaceutical development
  • Deep scientific experience with emphasis on I/O-related biomarkers, in- depth knowledge of oncology, clinical development perspective, and expertise in matrix-based management
  • Strong background in preclinical development required for IND/NDA filing
  • Experience in designing and executing biomarker assays for clinical implementation
  • Deep understanding of concepts and processes in therapeutic design and evaluation in oncology
  • Ability to work independently in a multi-disciplinary, fast-paced biotech environment
  • Proven track record of ability to conduct research with strong attention to detail in written publications and patent applications
  • Experience in directly managing CROs and/or researchers
  • Excellent problem solving, planning, verbal and written communication, project and resource management, and computer skills
  • Ability to analyze data, draw conclusions, expertise in statistical analysis, and present findings to scientists, clinicians, investors, and laypersons
  • Familiarity with cGMP manufacturing and CMC requirements in regulatory filings
  • As an action-oriented self-starter, you are eager to apply your expertise in diagnosing inefficiencies, determining root causes, and recommending solutions to complex challenges
  • Thorough understanding of clinical methodologies, provide sound analytical support, and quickly establish credibility as a reliable resource
  • Experience with adoptive cell therapy, with genome editing and stem cell experience preferred
  • Ability to work productively with and influence diverse project leads, and work with cross-functional project teams
  • Ability to think strategically and execute tactically
  • Experience working in a culture where courage, commitment, and excellence are the backbone of the leadership profile

 

Caribou compensation and benefits include:

  • Comprehensive compensation package including stock options and employee stock purchase program
  • Generous paid vacation time in addition to Company-observed holidays and floating holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan including matching employer contributions
  • Tuition reimbursement program

 

Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. 

 

Caribou is on Twitter. Follow the Company @CaribouBio.


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  • Location
    Berkeley, California
  • Department
    125 - In-vivo Pharmacology
  • Employment Type
    Full-Time
  • Minimum Experience
    Executive