Process Development Associate

165 - Process Development · Berkeley, California
Department 165 - Process Development
Employment Type Full-Time
Minimum Experience Mid-level

Process Development Associate


Caribou Biosciences is a clinical-stage biopharmaceutical company founded in 2011 by pioneers in CRISPR genome editing and headquartered in Berkeley, California. The company’s mission is to develop innovative, transformative therapies for patients with devastating diseases through novel genome editing. Caribou leverages its proprietary technologies to develop a wholly owned pipeline of genome-edited, off-the-shelf immune cell therapies, including CAR-Ts and CAR-NKs, for the treatment of multiple different types of cancer. Caribou believes that advanced genome editing is necessary to develop sophisticated cell therapies to treat a variety of malignancies.

 

Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, their contributions are recognized, and their needs are met.

 

We are seeking a motivated and experienced cell therapy Process Development Associate to join our Technical Operations team in Berkeley. The ideal candidate will interact with team members across the organization and provide Analytical Development support to the Company.

 

Principal Duties and Responsibilities:

  • Develop cGMP-compatible CAR-T cell separation, cell enrichment, cell expansion, gene editing, final formulation and related processes for scale-up
  • Use engineering principles to leverage bench and pilot scale models for cell therapy manufacturing process performance characterization
  • Participate in technical transfer of technologies to CMO/ and provide training and on-going technical support
  • Design and execute characterization studies, evaluate product impact of scale-up and/or raw material changes
  • Optimize scale-up of operations compatible with applicable quality assurance guidelines
  • Generate development reports and prepare SOPs and batch records
  • Participate in cross-functional teams, working in a highly matrixed team environment to advance preclinical program

 

Requirements (skills, education, experience, etc.): 

  • Bachelor’s or Master’s degree in Biology or a related field
  • Minimum of 2 years of experience in pharma or biotech, preferably working in process development and/or manufacturing operations
  • Experience with cell culture, cell-based assays and a working knowledge of cell biology/immunology
  • Excellent verbal and written communication skills
  • Proven ability to work independently, as well as to collaborate with peers and work effectively in a fast-paced team-oriented environment
  • Strong organizational, time management, communication and interpersonal skills


Pluses:

  • Experience with CAR-T cell process development
  • Experience with multi-color flow cytometry
  • Experience interacting with CMO partners
  • Background in immunology or immune cell engineering
  • Experience developing and tech transferring cell therapies toward GMP-Manufacturing
  • Experience with statistical design of experiments, advanced data analysis and Quality by Design concepts

 

Caribou compensation and benefits include:

  • Comprehensive compensation package including stock options and employee stock purchase program
  • Generous paid vacation time in addition to Company-observed holidays and floating holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan including matching employer contributions
  • Tuition reimbursement program

 

Caribou is an equal opportunity employer and does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. 

 

Caribou is on Twitter. Follow the Company @CaribouBio.

 

 

 

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  • Location
    Berkeley, California
  • Department
    165 - Process Development
  • Employment Type
    Full-Time
  • Minimum Experience
    Mid-level